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Poetry Brings Science to Life: Mitophagy and Biogenesis
Mitophagy and Biogenesis
mTOR and nutrient sensors control
Autophagy processes in all of our cells
Dozens of proteins must play each their role
To enable engulfment of bad organelles
Those who are young may mistakenly think one
Is safe and immune to the dangers of aging
But if you are lacking in proper PINK1
Mitochondrial fires are already raging.
For insight and knowledge some turn to the fly;
Drosophila’s genes can help us discover
The causes of aggregates seen in the eye,
And even find drugs to help us recover.
Ubiquitin’s role in degeneration
Is to set out red flags on relevant cargo
Marking the junk that needs degradation
At a pace that is presto rather than largo.
Mitochondria fear Parkin known as PARK2
Whose ubiquitin tags on two mitofusins
Determine the fate of one or a slew,
For a lonely short life of network exclusion.
Their fate is ensured by sequestosome 1
Who recruits membranes rich with LC3-II
Autophagosome to lysosome a perfect home run
Cellular housekeeping momentarily through.
But the work isn’t over and the job isn’t done
Unless Paris is tagged with ubiquitin too
Then repression is lifted form PGC1
So biogenesis starts and mitos renew!
Roberta A. Gottlieb
Dr. Roberta Gottlieb, author of Autophagy in Health and Disease, epitomizes the passion and intensity with which researchers and contributors are approaching the study of autophagy, as she composes unique poems to accompany the volumes of an exciting, cutting-edge series on the subject.
Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. It offers an up-to-date overview of autophagy with a translational focus, organized by organ, tissue and disease process.
The scope of life sciences is as vast as the variety of life on Earth: mathematical biology, developmental biology, molecular and cell biology, parasitology and virology, microbiology and immunology — the list goes on. Elsevier, through its renowned imprints like Academic Press, provides high-quality content in all of these areas that supports learning, teaching, and research. Our books, eBooks, journals, and online tools are cross-disciplinary, allowing academics and professionals to effectively learn about science outside their areas of focus.