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Poetry Brings Science to Life: Autophagy and Cancer
Autophagy and Cancer
When speaking of cancer, autophagy’s good
By culling mitochondria and clearing deadwood
Autophagy limits the radical chain
That breaks DNA and mutates a gene
That makes a cell double, so careless and mean
In order for cells to malignant transform
They lose mitochondria except for a few
Using glycolysis as the source of their fuel
How they achieve mitochondrial decimation
Is nothing more than autophagic elimination
Then one cell is many, an ominous mass
Demanding more glucose, hungry and crass,
Directing formation of artery and vein
Til capsular fibers give way under strain
Then cancer cells spread so far and so wide
They demand blood vessels the body provide
But until those are patent the tumor cells strive
To rely on autophagy to neatly survive
The hurdles required for metastasis
Until blood flow’s established for cancerous bliss.
Blocking autophagy sends them over the brink
And how chloroquine works, we think
But tumors are slowed by statin’s effects
Which induce autophagy and tumor cell death
Autophagy’s good, autophagy’s bad
The confusion’s enough to drive us all mad
So study we must, and learn ever more
Til enlightenment finally opens the door
Oncologists must heed the tumor’s agenda
And decide whether autophagy is foe or a friend-a.
Roberta A. Gottlieb
Dr. Roberta Gottlieb, Elsevier author of Autophagy in Health and Disease, epitomizes the passion and intensity with which researchers and contributors are approaching the study of autophagy, as she composes unique poems to accompany the volumes of an exciting, cutting-edge series on the subject.
Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. It offers an up-to-date overview of autophagy with a translational focus, organized by organ, tissue and disease process.
The scope of life sciences is as vast as the variety of life on Earth: mathematical biology, developmental biology, molecular and cell biology, parasitology and virology, microbiology and immunology — the list goes on. Elsevier, through its renowned imprints like Academic Press, provides high-quality content in all of these areas that supports learning, teaching, and research. Our books, eBooks, journals, and online tools are cross-disciplinary, allowing academics and professionals to effectively learn about science outside their areas of focus.