Neuroscience

Mechanism of Thought Generation in Neurons Unraveled

By: , Posted on:

A conceptual breakthrough!

The Biology of Thought_Color KG

A watercolor original from Krishnagopal Dharani

These are some of the brain’s mind-boggling questions:

  • How can the human brain generate thoughts?
  • What are the fundamental units of thought?
  • How do neurons store memory in them?
  • What precisely are the phenomena of mind and consciousness?

And, here is the conceptual breakthrough:

  • A molecular mechanism of thought generation unraveled!
  • The characteristics of primary thoughts defined!
  • The formation and storage of memory explained!
  • Mind and consciousness defined with unparalleled clarity!

This line-up of question-and-answers might sound too optimistic – but here is an evidence-based study of the brain and the neurons and their electrical events, which leads us to an unimpeachable conclusion of the mechanism of generation of thoughts in the neurons – a ground-breaking theory, all for the first time in the history of human thought! The hitherto abstract thought is finally shown to have a physical presence in the human brain – a historical landmark indeed!

The “Molecular-Grid Model” (as presented in the book The Biology of Thought) expounds a mechanism situated in the neurons by which they can convert the sensations received from the external world into fundamental units of thought at the neuronal level, called primary thoughts. A clear molecular mechanism is shown by which these primary thoughts thus generated are registered and encoded in the brain in their neuronal networks leading to the formation of memory of the things and events we receive form the external world. This model also delineates a mechanism for memory recollection and forgetfulness. Alongside, the physiological basis of such phenomena of the brain as intelligence and others is clearly defined.

The most evasive phenomenon of the human brain is the definition of mind or consciousness. Historically, these abstract cerebral phenomena have eluded precise scientific definition and thus are relegated to the grey areas of science and philosophy. The molecular-gird model helps us to understand mind and consciousness in a clear perspective and without confusion – and lends us some unprecedented definitions. By the way, the evolutionary basis of emotions, psychosomatic disorders and other such related problems becomes apparent.

Finally, this new model lets us a molecular peek into the age-old philosophical conundrum – the mind-matter problem – and leads us into newer insights of metaphysical issues of thought.

The Biology of ThoughtThe book, The Biology of Thought, presents the molecular-grid model in an academic style divided into easy-to-read parts.

More about the book…

This book describes the theory of molecular-grid model which is developed basing on the established principles of neuroscience, and is presented in four parts. The initial chapters of the book provide us with the fundamental principles in neuroscience – the structure of the brain and its physiology, and an analysis of the recent concepts in memory. In the subsequent chapters the fundamental nature of human thought is examined and the concept of primary thought developed. The crux of the molecular-grid model is presented in a stepwise manner, first identifying the neurons responsible for sensory perception and later deciphering the portion of neuron responsible for converting sensory inputs into primary thoughts. The molecular-grids themselves are then studied regarding their structure and mechanism.

Having envisaged the mechanism of generation of primary thoughts, the theory is put to test by applying it to explain the intriguing mechanism of memory, forgetfulness, intelligence and other related brain functions. A critical examination of thought allows us to explain the abstract phenomena of mind and consciousness. The book consists of an astounding analysis of concepts in neurobiology, looking at them in a new light, and leading to a concrete theory of thought generation and memory. Finally, as a matter of comparing brain with computer, the molecular-grids are shown to have a striking resemblance to the transistors in a computer.

The book, The Biology of Thought, unfolds the answers to the mysterious questions in neuroscience and neurophilosophy, which have fascinated and bewildered human beings since time immemorial.

About the Author

KG PhotoKrishnagopal Dharani is a medical doctor practicing at Adoni, a large town in South India. He has graduated in medicine from Kurnool Medical College in Andhra Pradesh, and did his general surgery from Kasturba Medical College, Manipal, South Canara. He took his post-doctoral specialization in vascular surgery at the Nizam’s Institute of Medical Sciences, Hyderabad. He is presently holding the post of Specialist Civil Surgeon in AP Medical Services, and despite having a large surgical practice, he manages to split his time between his profession and his academic pursuits in science.

Dr. KG is a critical thinker and a creative writer who perpetually investigates into the elementary issues of science, and seeking simple answers to the most complex questions that bothered mankind for ages. He is a freelance science promotional writer, and his writings were published in various science journals across India such as ScienceIndia, Amity College of Biotechnology, local magazines and others. He has varied interests in diverse fields of science ranging from biology to theoretical physics and has participated in several debates. He has done some basic research on the problem of origin of life on the earth and is at present involved in a theory of abiogenesis from primordial membranes.

The author is an accomplished artist, did several paintings to his credit, and as a matter of fact, all the innovative figures in The Biology of Thought are the products of his artwork. He is a staunch social activist and a Rotarian participating in several community developmental activities concerning especially of health and education.

25 Comments

  • Sir , It is wonderful to know the the book, I like to know when will be available in our Indian Market.Hope soon.-Ramavara prasad

  • sitaram says:

    quite interesting i would like to know when is the book slated to be released especially in India.

  • dr b ramesh babu kurnool says:

    Excellent ideas &evidence based workup ; useful& thought provoking to younger generation.

    • KG Dharani says:

      Thank you Dr Ramesh for your comment. It sure is an evidence-based work, and hopefully opens up new avenues in the field of neuroscience.

  • Mannava Sathyavathi says:

    Wow! This is innovative. Next month is the release, is it!

    • KG Dharani says:

      Cheers Sitaram – The book will be released on the 15th of September in the International Market – in India a little later I suppose. I’ll let you know anyway!

  • Nick says:

    Very interesting! As a future neuroscientist I am particularly interested in this book. I was wondering if you had any published articles about this work that I could access. The only one I was able to find online, I was unable to access. Thanks for your time! I don’t know if it’s okay to post my email here, but it’s the easiest way to contact me. Nicholas.E.Woodruff-1@ou.edu

  • TEDDY TALBOT says:

    Hi Doctor Krishnagopal Dharani, I would like to know, when you book will be released in my country: Brazil!!

    Thank you!!

    • KG Dharani says:

      Hmm… The book will be released into the international market by Sep 15, — Europe certainly, but Brazil I’ve to find out! Anyway thanks a lot for the interest in my book – KG

  • It sound quite interesting! Thank you, I will surely read this interesting book!

    • KG Dharani says:

      Thank you for your great interest in my book. You’d sure enjoy reading it! It appears we may have some interesting give-n-take in future
      - KG

  • Badri Soma says:

    Amazing work. I am proud of you. I am straight ordering the book for my reading.
    I am really proud of your creative thoughts

    • KG Dharani says:

      Thanks a lot Badri – you know that was really nice of you!! And a lot encouraging – hope word goes around in Australia too!!

  • Sharon Davis says:

    I am very interested in buying this book

  • Veenapani Dharani says:

    Congratulations Gopal! Really proud of you!!

  • Emmanuel Prikas says:

    Hey this sounds amazing. I will order it right away. I should just read it and answer this question myself, but I was hoping u could. I’m halfway through Terrance Deacons’ “Incomplete Nature: how mind emerged from matter”. Have u read this? And are u in agreance with anything put forth in it?? Thanks in advance

    • KG Dharani says:

      You would sure find my book interesting! The book uses all the physiological concepts in neuroscience to arrive at a molecular model – no philosophical ambiguities or abstract theories – it’s all there for you to see!! No worries – “The Biology of Thought” is direct and comes to the point straight – meanwhile you can make attempts yourself – Cheers.
      Yes I know of “Incomplete Nature” – an interesting and highly scholarly work indeed!

Leave a Reply

Your email address will not be published. Required fields are marked *

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>

The scientific study of the nervous system is entering a new golden age. Researchers and clinicians continue to advance the treatment of conditions such as Alzheimer’s syndrome, Parkinson’s disease, epilepsy, and traumatic brain injury. Public initiatives like the federal Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) program in the United…

Read more




Browse other articles in this category: