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For Curing Alzheimer’s Disease, It’s Inside that Counts
What is the take-home message from the series of failed amyloid-based clinical trials? Simply stated, removing extracellular amyloid as plaques in the brain does not cure Alzheimer’s disease. But before amyloid is taken off the list of targets to cure Alzheimer’s, perhaps it is the amyloid inside the cells that requires the attention.
In my recently released book, Intracellular Consequences of Amyloid in Alzheimer’s Disease, a great deal of the references concerns the natural and pathological consequences of intracellular amyloid in neurons. Amyloid, specifically Abeta, is important in many natural biological processes (e.g., learning), however, Abeta is also involved in many pathological processes in Alzheimer’s disease (e.g., vascular system). The evidence presented in this book suggests that perhaps it is the “toxic accumulation” of amyloid and not the accumulation of “toxic amyloid” in neurons that leads to their demise and Alzheimer’s disease.
This book provides a comprehensive inventory of references (>1,000) that reports many important intracellular aspects of amyloid in Alzheimer’s while providing a framework of scientific reports for the reader to draw their own hypotheses. As a reference book, the reader can also seek further information from the many cited review articles on the topic and is recommended for any scientist pursuing amyloids’ role in Alzheimer’s disease.
About the author:
Michael R. D’Andrea has a PhD in Cell and Developmental Biology and an MS in Molecular Biology. He has authored over 100 scientific publications, including invited review papers on Alzheimer’s disease, and co-invented 11 patents. He is also the author of the book Bursting Neurons and Fading Memories: An Alternative Hypothesis of the Neuropathology of Alzheimer’s Disease, An exciting resource describing alternatives to the prevailing amyloid hypothesis of Alzheimer’s disease, illuminating new avenues of clinical direction. You can read his complete bio here and his other SciTech Connect articles here.
To purchase your copy of Intracellular Consequences of Amyloid in Alzheimer’s Disease or Bursting Neurons and Fading Memories visit the Elsevier Store. Apply discount code STC215 and save up to 30% off the list price. You can also purchase both the print and electronic versions at 40% off the list price. Both options include free global shipping.
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