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Arousal in Neurological and Psychiatric Disorders

By: , Posted on: July 11, 2019

Most books deal with only a single disease or with only psychiatric disorders or only neurological disorders.  Arousal in Neurological and Psychiatric Disorders details the similarities (which are considerable) across the spectrum of arousal problems, as well as the differences between disorders and what these problems  mean for patients.  Emphasis will be on how disorders of arousal help explain a host of symptoms in neurological and psychiatric disorders.  For example, what does the schizophrenic patient look like, how is he described?  “Loss of affect”.  What does the Parkinson’s patient look like?  “Masked facies”.  What does the Alzheimer’s or depressed patient look like?  Blank stare, lack of spontaneous facial movement, lack of expression.  They are called different things in different patients but are all basically the same expression and are mainly due to the same cause, decreased frontal lobe blood flow, which is highly indicative of increased arousal.

Chapter 8 – Arousal and the Alzheimer disease is available to read now on ScienceDirect for a limited time.

The book aims to focus attention on dysregulation of arousal, which is found in all of the neurological and psychiatric disorders described.  The benefit comes from the understanding of the basic mechanisms that modulate arousal in health but also in disease, and also from the realization that therapies that address arousal dysregulation can alter the severity and manifestation of multiple disorders.  The most significant contribution is that this book describes the physiology of each process, how it is disturbed in each disorder, and what the most appropriate treatment(s) should be.  The second contribution is the understanding of the Reticular Activating System as a complex not only modulating waking, but which is also in charge of survival mechanisms such as fight vs flight responses and reflexes.  The full spectrum of these functions helps explain the complexity of symptoms evident in such disorders as disparate as schizophrenia and Parkinson’s disease.  The purpose will be to develop an understanding of this homeostatic mechanism that has synergistic action with other such mechanisms as appetite.  No books in the market deal with the function of the RAS with respect to higher functions, motor control, and the intertwining of arousal and motor disorders.  This has great explanatory power when considering treatments for neurological and psychiatric disease

Most books in the field of neurology or psychiatry deal with one disorder or present a tome of symptomatology and treatment, e.g. “Neurological disorders, course and treatment”.  Or they present an overview of a host of disorders with listings of either basic or clinical findings without explanatory power, such as “Neurological and Psychiatric disorders”.  There is a great need to address the mechanisms that control waking and arousal, and especially how those mechanisms malfunction in specific neurological and psychiatric disorders, which this book aims to meet.


About the book

  • Provides a comprehensive overview of the basic mechanisms behind dysregulation of arousal in neurological and psychiatric disorders
  • Describes, in detail, the function of the Reticular Activating System with respect to higher functions, motor control and the intertwining of arousal and motor disorders.
  • Covers multiple neurological disorders, including epilepsy, Alzheimer’s disease, Parkinson’s disease and autism

The book is available now on ScienceDirect. For a limited time you can read Chapter 8: Arousal and the Alzheimer disease. Want your own copy? Order via the Elsevier Store and enter code STC319 at the checkout to save up to 30%


About the Editor:

Dr. Edgar Garcia-Rill is a Professor of Neurobiology and Developmental Sciences, and Psychiatry in the College of Medicine at the University of Arkansas for Medical Sciences (UAMS). He also holds graduate faculty appointments in the Neurobiology and Developmental Sciences and Interdisciplinary Biomedical Sciences program. He is the Director of the Center for Translational Neuroscience, a Center of Biomedical Research Excellence.

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The scientific study of the nervous system is entering a new golden age. Researchers and clinicians continue to advance the treatment of conditions such as Alzheimer’s syndrome, Parkinson’s disease, epilepsy, and traumatic brain injury. Public initiatives like the federal Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) program in the United States, announced in April 2013, ensure that funding and resources will continue to be applied to this rapidly growing field. Elsevier’s journals, books, eBooks, online references, and tools are respected around the world for everything from physiology and pathology to behavioral genetics and nerve repair. Our publications are a gateway to the latest advancements in neuroscience research and leading-edge data for professionals, students, and academics alike.